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  • 437725 - Lipoxin A₄, 15-epi - CAS 171030-11-8 - Calbiochem

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437725 Sigma-Aldrich

Lipoxin A₄, 15-epi - CAS 171030-11-8 - Calbiochem

Lipoxin A₄, 15-epi, CAS 171030-11-8, is an epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4.

Synonym: LXA₄-15-epi, 15( R)-LXA₄, Aspirin-triggered LXA₄, (5 S,6 R,15 R)-5,6,15-Trihydroxy-7,9,13- trans-11- cis-eicosatetraenoic acid, LXA₄-15-epi, 15(R)-LXA₄, Aspirin-triggered LXA₄, (5S,6R,15R)-5,6,15-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid

  • CAS Number 171030-11-8

  • Empirical Formula (Hill Notation) C20H32O5

  • Molecular Weight 352.47

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Properties

Related Categories Biochemicals and Reagents, Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls, Lipids
packaging   25 μg in Glass bottle (437725-25UG)
form   liquid
shipped in   wet ice
storage condition   OK to freeze
  desiccated
  protect from light
brand family   Calbiochem
purity   ≥98% by HPLC
storage conditions   = -70C

Description

Biochem/physiol Actions

Cell permeable: no

Primary Target
Exhibits anti-inflammatory properties

Product does not compete with ATP.

Reversible: no

General description

A epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Blocks TNF-α-induced IL-8 release in human enterocyte. It is also an important modulator of the many pharmacological actions caused by aspirin.

An epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Reported to block TNF-α-induced IL-8 release in human enterocytes. Also reported to be an important modulator of the pharmacological actions of aspirin.



Caution! Product contains volatile liquid; keep cold at all times.

Caution! Product contains volatile liquid. Keep product cold at all times.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Wallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci.24, 323.
Filep, J.G., et al. 2002. Adv. Exp. Med. Biol.507, 223.
Titos, E., et al. 1999. Am. J. Physiol.277, C870.
Gronert, K., et al. 1998. J. Exp. Med.187, 1285.
Maddox, J.F., et al. 1997. J. Biol. Chem.272, 6972.
Claria, J., et al. 1996. Mol. Med.2, 583.
Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA92, 9475.
Serhan, C.N., et al. 1995. Biochemistry34, 14609.

Packaging

25 μg in Glass bottle

Packaged under inert gas

Reconstitution

Following initial thaw aliquot and freeze (-70°C).

Warning

Flammable (J)

Physical form

In Ethanol.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
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