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443300 Sigma-Aldrich

MCI-186 - CAS 89-25-8 - Calbiochem

A free radical scavenger and antioxidant that reduces post-ischemic brain injury.

Synonym: 3-Methyl-1-phenyl-2-pyrazolin-5-one, PMP, Edaravone, MCI-186 - CAS 89-25-8 - Calbiochem

  • CAS Number 89-25-8

  • Empirical Formula (Hill Notation) C10H10N2O

  • Molecular Weight 174.20

  •  MDL number MFCD00003138

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Properties

Related Categories Antioxidant and Free Radical Scavengers, Cancer Research, Cell Biology, Chemopreventive Agents
Quality Level   100
assay   ≥98% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   cream
solubility   DMSO: 100 mg/mL
shipped in   ambient
InChI   1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
InChI key   QELUYTUMUWHWMC-UHFFFAOYSA-N

Description

General description

A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 µM). Inhibits mitochondrial permeability transition pore.

A free radical scavenger and antioxidant that reduces post-ischemie brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 µM). Inhibits mitochondrial permeability transition pore.

Packaging

500 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
A free radical scavenger and antioxidant

Product does not compete with ATP.

Reversible: no

Target IC50: 15 µM inhibiting iron-dependent peroxidation in rat brain homogenates

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Katare, R. G., et al. 2003. Am. J. Physiol.285, H2171.
Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
Nishi, H., et al. 1989. Stroke 20, 1236.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
WGK Germany 
WGK 1
Protocols & Articles
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