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444283 Sigma-Aldrich

MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem

The MMP-13 Inhibitor, also referenced under CAS 544678-85-5, controls the biological activity of MMP-13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym: MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem, Pyrimidine-4,6-dicarboxylic acid, bis-(4-fluoro-3-methyl-benzylamide)

  • CAS Number 544678-85-5

  • Empirical Formula (Hill Notation) C22H20F2N4O2

  • Molecular Weight 410.42

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, L to O,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   light yellow
solubility   DMSO: 10 mg/mL
shipped in   ambient

Description

General description

A potent inhibitor of MMP-13 activity (IC50 = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.

A pyrimidine dicarboxamide compound that potently inhibits MMP-13 activity (IC50 = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.

Packaging

1 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
MMP-13 activity

Product does not compete with ATP.

Reversible: no

Target IC50: 8 nM against MMP-13

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Preparation Note

Further dilute in buffer immediately prior to use.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Engel, C.K., et al. 2005. Chem. Biol.12, 181.

Safety & Documentation

Safety Information

WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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