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454180 Sigma-Aldrich

2-Methoxyestradiol - CAS 362-07-2 - Calbiochem

A natural metabolite of 17β-estradiol that is devoid of estrogenic activity.

Synonym: 2-Methoxy-3,17β-dihydroxyestra-1,3,5(10)-triene, 2-Methoxy-3,17β-dihydroxyestra-1,3,5(10)-triene

  • CAS Number 362-07-2

  • Empirical Formula (Hill Notation) C19H26O3

  • Molecular Weight 302.41

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Properties

Related Categories Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology More...
packaging   10 mg in Alu drum (454180-10MG)
  50 mg in Alu drum (454180-50MG)
color   white
form   crystalline solid
shipped in   ambient
solubility   DMSO: soluble
  ethanol: soluble
storage condition   OK to freeze
brand family   Calbiochem
purity   ≥90% by HPLC
storage conditions   +15C to +30C

Description

Biochem/physiol Actions

Cell permeable: no

Primary Target
Inhibits cell proliferation and angiogenesis

Product does not compete with ATP.

Reversible: no

General description

A natural metabolite of 17β-estradiol that is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Markedly inhibits neovascularization of solid tumors and suppresses tumor growth in mice. Binds to the colchicine binding site of tubulin and has been suggested to function as a natural regulator of microtubule assembly and function.

A natural metabolite of 17β-estradiol that is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Markedly inhibits the neovascularization of solid tumors and suppresses tumor growth in mice. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.

Other Notes

Aizu-Yokata, E., et al. 1995. Cancer Res.55, 1863.
Cushman, M., et al. 1995. J. Med. Chem. 38, 2041.
D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3964.
Forsis, T., et al. 1994. Nature368, 237.

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Packaging

10, 50 mg in Alu drum

Warning

F

Safety & Documentation

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Certificate of Analysis

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