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8-Methoxymethyl-3-isobutyl-1-methylxanthine - CAS 78033-08-6 - Calbiochem

A cell-permeable selective inhibitor of Ca2+-calmodulin-dependent phosphodiesterase (PDE I; IC₅₀ = 4 µM).

Synonym: 8-Methoxymethyl-3-isobutyl-1-methylxanthine - CAS 78033-08-6 - Calbiochem, 8-Methoxymethyl-IBMX

  • CAS Number 78033-08-6

  • Empirical Formula (Hill Notation) C12H18N4O3

  • Molecular Weight 266.30

  •  MDL number MFCD00211081

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors More...
Quality Level   100
assay   ≥98% (TLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   +15C to +30C
color   white
solubility   ethanol: 2 mg/mL
  DMSO: 5 mg/mL
shipped in   ambient
InChI   1S/C12H18N4O3/c1-7(2)5-16-10-9(11(17)15(3)12(16)18)13-8(14-10)6-19-4/h7H,5-6H2,1-4H3,(H,13,14)
InChI key   NBLBCGUCPBXKOV-UHFFFAOYSA-N

Description

General description

A cell-permeable selective inhibitor of Ca2+-calmodulin-dependent phosphodiesterase (PDE I; IC50 = 4 µM).

A cell-permeable, selective inhibitor of Ca2+-calmodulin-dependent phosphodiesterase (PDE I, IC50 = 4 µM).

Packaging

10 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PDE 1

Product does not compete with ATP.

Reversible: no

Target IC50: 4 µM against Ca2+-calmodulin-dependent phosphodiesterase (PDE I)

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Jackson, E.K., et al. 1997. J. Cardiovasc. Pharmacol. 30, 798.
Ahn, H.S., et al. 1989. Biochem. Pharmacol.38, 3331.
Han, P., et al. 1989. J. Biol. Chem.274, 22337.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles
Peer-Reviewed Papers
15

References

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