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  • 475250 - 4-{[3ʹ,4ʹ-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline

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475250 Sigma-Aldrich

4-{[3ʹ,4ʹ-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline

Synonym: 4-{[3ʹ,4ʹ-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline

  • Empirical Formula (Hill Notation) C17H15N3O3

  • Molecular Weight 309.32

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors More...
Quality Level   100
assay   ≥98% (HPLC)
form   solid
potency   230 nM IC50
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   +2C to +8C
color   white
solubility   DMSO: 5 mg/mL
shipped in   ambient

Description

General description

Potent and specific inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50 = 230 nM). Elevates the intracellular cGMP level without causing a change in the cAMP level in isolated porcine coronary arteries. Has no effect on other PDE isoenzymes.

Potent and specific inhibitor of cGMP-specific phosphodiesterase (PDE V; IC50 = 230 nM). Elevates the intracellular cGMP level without causing any change in the cAMP level in isolated porcine coronary arteries. Has no effect on other PDE isozymes.

Packaging

5 mg in Glass bottle

Biochem/physiol Actions

Primary Target
CGMP-PDEV

Warning

Toxicity: Standard Handling (A)

Other Notes

Takase, Y., et al. 1994. J. Med. Chem.37, 2106.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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