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475837 Sigma-Aldrich

MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem

MIF Antagonist, ISO-1, CAS 478336-92-4, is a cell-permeable inhibitor of MIF tautomerase (IC50 = 7 µM for D-dopachrome tautomerase). Suppresses the production of TNFα, PGE2 & COX-2 in monocytes.

Synonym: (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester, Macrophage Migration Inhibitory Factor Antagonist, ISO-1

  • CAS Number 478336-92-4

  • Empirical Formula (Hill Notation) C12H13NO4

  • Molecular Weight 235.24

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Properties

Related Categories Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology More...
packaging   5 mg in Plastic ampoule (475837-5MG)
color   light yellow
form   solid
shipped in   wet ice
solubility   DMSO: 10 mg/mL
storage condition   OK to freeze
  protect from light
brand family   Calbiochem
primary target IC50   7 µM for D-dopachrome tautomerase
purity   ≥98% by HPLC
storage conditions   -20C

Description

Biochem/physiol Actions

Cell permeable: yes

Primary Target
MIF tautomerize

Product does not compete with ATP.

Reversible: no

Target IC50: 7 µM for D-dopachrome tautomerase

General description

A cell-permeable isoxazoline compound that displays anti-inflammatory properties. Inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. Shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.

A cell-permeable isoxazoline compound that displays anti-inflammatory properties. Inhibits MIF tautomerase activity by binding to its catalytic active site (IC50 = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes, and arachidonic acid in RAW 264.7 macrophages. Shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model. Also available as a 50 mM solution in DMSO (Cat. No. 505225).

Other Notes

Cvetkovic, I., et al. 2005. Endocrinology, 146, 2942.
Lubetsky, J.B., et al. 2002. J. Biol. Chem.277, 24976.

Packaging

5 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Standard Handling (A)

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
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