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475840 Sigma-Aldrich

Milrinone - CAS 78415-72-2 - Calbiochem

A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 300 nM).

Synonym: 1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile, Milrinone - CAS 78415-72-2 - Calbiochem

  • CAS Number 78415-72-2

  • Empirical Formula (Hill Notation) C12H9N3O

  • Molecular Weight 211.22

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors More...
Quality Level   100
assay   ≥99% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
color   white
solubility   DMSO: 20 mg/mL
  ethanol: 3 mg/mL
shipped in   ambient

Description

General description

A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III, IC50 = 300 nM). Has positive chronotropic, ionotropic, and vasodilatory effects on the heart.

A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 300 nM). Has positive chronotropic, inotropic, and vasodilatory effects on the heart.

Packaging

10 mg in Alu drum

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PDE 3

Product does not compete with ATP.

Reversible: no

Target IC50: 300 nM against PDE III

Warning

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Bailey, J.M., et al. 1994. Anesthesiology 81, 616.
Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol.20, 705.
Lindgren, S.H., et al. 1990. Acta. Phys. Scand.140, 209.
Harrison, S.A., et al. 1986. Mol. Pharmacol.29, 506.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Safety & Documentation

Safety Information

RTECS 
DW1762000
Protocols & Articles
Peer-Reviewed Papers
15

References

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