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475856 Sigma-Aldrich

Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem

The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.

Synonym: Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor, 3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one, Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem

  • CAS Number 338967-87-6

  • Empirical Formula (Hill Notation) C15H10Cl2N2O2S

  • Molecular Weight 353.22

  •  MDL number MFCD00974506

  •  NACRES NA.77

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Mitochondrial Inhibitors, Nitric Oxide and Cell Stress More...
Quality Level   100
assay   ≥95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   -20C
color   white
solubility   DMSO: 10 mg/mL
shipped in   wet ice

Description

General description

A cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC50 = 10 and 50 µM in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC50< 10 µM) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- (Cat. Nos. 569396 and 569397) as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release.

A cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC50 = 10 and 50 µM in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC50<10 µM) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- (Cat. Nos. 569396 & 569397) as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release.

Packaging

10 mg in Plastic ampoule

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Cassidy-Stone A., et al. 2008. Dev. Cell14, 193.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles
Peer-Reviewed Papers
15

References

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