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475870 Sigma-Aldrich

MnTBAP - Calbiochem

Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.

Synonym: Mn(III)tetrakis(4-benzoic acid)porphyrin Chloride, MnTBAP - Calbiochem

  • CAS Number 55266-18-7

  • Empirical Formula (Hill Notation) C48H28ClMnN4O8

  • Molecular Weight 879.15

  •  NACRES NA.77

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Properties

Related Categories Antioxidant and Free Radical Scavengers, Cancer Research, Cell Biology, Chemopreventive Agents
Quality Level   100
assay   ≥95% (TLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   -20C
color   brown
solubility   aqueous base: soluble
shipped in   ambient

Description

General description

Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).

Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of dihydrorhodamine-123 by peroxynitrite, but does not scavenge nitric oxide (NO).

Packaging

25 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

EC50 ~40 µM in protecting endothelial cells against paraquat (2 mM)

Primary Target
Superoxide dismutase (SOD) mimetic

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Aladag, M. A., et al. 2003. Acta Neurochir.145, 673.
Szabo, C., et al. 1996. FEBS Lett. 381, 82.
Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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