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475880 Sigma-Aldrich

ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM).

Synonym: 1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl, ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem

  • CAS Number 110448-33-4

  • Empirical Formula (Hill Notation) C15H17IN2O2S · xHCl

  • Molecular Weight 416.28 (free base basis)

  •  MDL number MFCD00065524

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Myosin Light Chain Kinase (MLCK), Serine/Threonine Kinase Biology,
Quality Level   100
assay   >98% (TLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   +2C to +8C
color   white
solubility   50% ethanol: 4.5 mg/mL
  DMSO: 4.5 mg/mL
shipped in   ambient
InChI   1S/C15H17IN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2
InChI key   GEHJIACZUFWBTK-UHFFFAOYSA-N

Description

General description

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM) and protein kinase C (Ki = 42 µM) at much higher concentrations.

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM)and protein kinase C (Ki = 42 µM) at much higher concentrations.

Packaging

1 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Myosin light chain kinase (Mlck)

Product competes with ATP.

Reversible: yes

Target Ki: 300 nM against myosin light chain kinase

Warning

Toxicity: Standard Handling (A)

Preparation Note

Further dilute with aqueous buffer just prior to use.

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Other Notes

Krarup, T., et al. 1998. Am. J. Physiol. 275, C239.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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