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475882-M Millipore

ML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (Ki = 3.8 µM), protein kinase A (Ki = 32 µM), and protein kinase C (Ki = 54 µM).

Synonym: 1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl, ML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem

  • CAS Number 105637-50-1

  • Empirical Formula (Hill Notation) C15H17ClN2O2S · xHCl

  • Molecular Weight 324.83 (free base basis)

  •  MDL number MFCD00065525

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Myosin Light Chain Kinase (MLCK), Serine/Threonine Kinase Biology,
assay   ≥98% (TLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   +2C to +8C
color   white
solubility   50% ethanol: 10 mg/mL
InChI   1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChI key   ZNRYCIVTNLZOGI-UHFFFAOYSA-N

Description

General description

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (Ki = 3.8 µM), protein kinase A (Ki = 32 µM), and protein kinase C (Ki = 54 µM). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.

Biochem/physiol Actions

Primary Target
Mlck

Target Ki: 3.8 µM, 32 µM, 54 µM against myosin light chain kinase, protein kinase A, and protein kinase C, respectively

Warning

Toxicity: Standard Handling (A)

Preparation Note

Further dilute with aqueous buffer just prior to use.

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Other Notes

Reig, J.A., et al. 1993. Neurochem. Res. 18, 317.
Nagatsu, T., et al. 1987. Biochem. Biophys. Res. Commun.143, 1045.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Saitoh, M., et al. 1986. Biochem. Biophys. Res. Commun.140, 280.

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