• USA Home
  • 480026 - NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem

EMAIL THIS PAGE TO A FRIEND
480026 Sigma-Aldrich

NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem

A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC₅₀~ 50 µM in HCT116 cells).

Synonym: NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem, NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD

  • Empirical Formula (Hill Notation) C123H197N47O32

  • Molecular Weight 2846.18

Purchase

Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Extracellular Matrix Peptides (ECM), Laminin Fragments, Peptides and Proteins,
Quality Level   100
assay   ≥95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   +2C to +8C
color   white
solubility   water: 50 mg/mL
shipped in   ambient

Description

General description

A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC50 ~ 50 µM in HCT116 cells). Acts by interfering with the formation of active IKK complex and thereby prevents IκBα phosphorylation and its subsequent proteasomal degradation. Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities. Colon-targeted capsules containing CTP-NBD are shown to reduce 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rodent models (4.5 mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators. Antennapedia fused NBD cell-permeable peptide is also available (>Cat. No. 480025).

Packaging

5 mg in Glass bottle

Biochem/physiol Actions

Cell permeable: yes

Primary Target
NEMO-binding peptide

Reversible: yes

Packaging

Packaged under inert gas

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-YGRRARRRARRTALDWSWLQTE-NH₂

Other Notes

Hong, S., et al. 2012. Mol. Pharm.9, 1310.
Kim, D., et al. 2006. Exp. Cell Res.312, 1277.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?