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480748 Sigma-Aldrich

Neuronal Differentiation Inducer, Isobavachin - Calbiochem

A cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM.

Synonym: 7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one, Isobavachin, Isobavachin, 7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one, Neuronal Differentiation Inducer, Isobavachin - Calbiochem

  • Empirical Formula (Hill Notation) C20H20O4

  • Molecular Weight 324.37

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cell Signaling and Neuroscience More...
Quality Level   100
assay   ≥95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   -20C
color   pale yellow
solubility   DMSO: 100 mg/mL, clear, yellow
shipped in   ambient

Description

General description

A cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM. It is shown to elicit the down-regulation of p38 and JNK phosphorylation, and the up-regulation of ERK phosphorylation. Co-treatment with GGTI-298 (1000 nM), a Geranylgeranyltransferase I Inhibitor (Cat. No. 345883) selectively abolishes the IBA- but not Retinoic Acid-induced neuronal differentiation, which suggests that the differentiation inducing effect may involve protein prenylation.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Wang, D.Y., et al. 2011. Acta Pharmacol Sin32, 425.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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