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487928 Sigma-Aldrich

Nocodazole - CAS 31430-18-9 - Calbiochem

Nocodazole, CAS 31430-18-9, is a highly specific anti-microtubular agent that promotes tubulin depolymerization and inhibits mitosis.

Synonym: R17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate, R17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate

  • CAS Number 31430-18-9

  • Empirical Formula (Hill Notation) C14H11N3O3S

  • Molecular Weight 301.32

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix More...
packaging   10 mg in Plastic ampoule (487928-10MG)
color   pale yellow
form   solid
mfr. no.   Calbiochem
shipped in   ambient
solubility   DMSO: 5 mg/mL
storage condition   OK to freeze
purity   ≥99% by HPLC
storage conditions   +15C to +30C

Description

Biochem/physiol Actions

Cell permeable: no

Primary Target
Promotes tubulin depolymerization

Product does not compete with ATP.

Reversible: no

General description

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (Kd< 2 µM).

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).

Other Notes

Park, H., et al. 2011. Chem. Med. Chem.in press.
Bunz, F., et al. 1998. Science 282, 1497.
Fleischman, L.F., et al. 1993. Oncogene8, 771.
Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.

Packaging

10 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.

Warning

Carcinogenic / Teratogenic (D)

Safety & Documentation

Safety Information

RTECS 
DD6521000

Documents

Certificate of Analysis

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Protocols & Articles
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