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488004 Millipore

Nodinitib-1 - Calbiochem

Synonym: NOD1 Signaling Inhibitor, Nucleotide-binding Oligomerization Domain 1 Signaling Inhibitor, CID-1088438, 1-((4-Methylphenyl)sulfonyl)-1H-benzimidazol-2-amine, ML130, 1-(Toluene-4-sulfonyl)-1H-benzimidazol-2-ylamine, Nodinitib-1 - Calbiochem

  • Empirical Formula (Hill Notation) C14H13N3O2S

  • Molecular Weight 287.34

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Properties

assay   ≥99% (HPLC)
form   powder
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   white
solubility   DMSO: 50 mg/mL, clear, colorless
shipped in   ambient

Description

General description

This product has been discontinued.



A cell-permeable aminobenzimidazole compound that acts as a potent, specific and reversible inhibitor of NOD1 (Nucleotide-binding Oligomerization Domain 1; NLRC1, CARD4, or CLR7.1)-induced NF-κB activation (IC50 = 0.56 µM, >20, and >20 by NOD1 ligand, NOD2 ligand and TNFα in HEK293T-NF-κB-luciferase cells, respectively). Shown to block phosphorylation and degradation of IκBα and MAPK signaling (5 µM in HCT-116 cells) with no effect on Akt pathway. Suggested to directly interact with NOD1, alter the conformation and suppress RIP2 trafficking, a NOD1-binding partner required for NF-κB induction.

A cell-permeable aminobenzimidazole compound that acts as a potent, specific and reversible inhibitor of NOD1 (Nucleotide-binding Oligomerization Domain 1; NLRC1, CARD4, or CLR7.1)-induced NF-κB activation (IC50 = 0.56 µM, >20, and >20 by NOD1 ligand, NOD2 ligand and TNFα in HEK293T-NF-κB-luciferase cells, respectively). Shown to block phosphorylation and degradation of IκBα and MAPK signaling (5 µM in HCT-116 cells) with no effect on Akt pathway. Suggested to directly interact with NOD1, alter the conformation and suppress RIP2 trafficking, a NOD1-binding partner required for NF-κB induction.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Khan, P.M., et al. 2011. ACS Med. Chem. Lett.2, 780.
Correa, R.G., et al. 2011. Chem. Biol.18, 825.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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