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506132 Sigma-Aldrich

Pifithrin-α - CAS 63208-82-2 - Calbiochem

A cell-permeable chemical inhibitor of p53.

Synonym: 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1- p-tolylethanone, HBr

  • CAS Number 63208-82-2

  • Empirical Formula (Hill Notation) C16H18N2OS · xHBr

  • Molecular Weight 286.39 (free base basis)

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Properties

Related Categories Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology More...
packaging   10 mg in Plastic ampoule (506132-10MG)
  5 mg in Plastic ampoule (506132-5MG)
color   off-white
form   solid
shipped in   ambient
solubility   DMSO: 100 mg/mL
storage condition   OK to freeze
  protect from light
brand family   Calbiochem
purity   ≥95% by HPLC
storage conditions   -20C

Description

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PS3

Product does not compete with ATP.

Reversible: yes

General description

A cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects normal tissues from the deleterious side effects of chemotherapy. Has been reported to protect neurons against β-amyloid peptide and glutamate-induced apoptosis.

A reversible inhibitor of p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects mice from lethal genotoxic stress associated with anticancer treatment without promoting tumor formation. Has been reported to protect neurons against β-amyloid and glutamate-induced apoptosis.

Other Notes

Murphy, P.J.M., et al. 2004. J. Biol. Chem.279, 30195.
Culmsee, C., et al. 2001. J. Neurochem.77, 220.
Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
Ferber, D. 1999. Science 285, 1651.
Jacquemin-Sablon, A. 1999. Bull. Cancer86, 894.
Komarov, P.G., et al. 1999. Science 285, 1733.

Packaging

5, 10 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.

Warning

Standard Handling (A)

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
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