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506156 Millipore

p38 MAP Kinase Inhibitor V - CAS 271576-77-3 - Calbiochem

The p38 MAP Kinase Inhibitor V, also referenced under CAS 271576-77-3, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: 4-(3-(4-Chlorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)pyrimidine, SC-409, 4-(3-(4-Chlorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)pyrimidine, SC-409

  • CAS Number 271576-77-3

  • Empirical Formula (Hill Notation) C19H20ClN5

  • Molecular Weight 353.85

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, L to O,
packaging   1 mg in Plastic ampoule (506156-1MG)
feature productdata solubility   DMSO (10 mg/ml) or Ethanol (5 mg/ml)
brand family   Calbiochem
form   Light yellow solid
primary target IC50   20 and 40 nM, against CK1δ and p38α, respectively
purity   ≥90% by HPLC
shipped in   ambient
storage conditions   -20C
  Protect from light
  Ok to freeze

Description

Biochem/physiol Actions

Cell permeable: yes

Primary Target
p38 MAP Kinase

Product competes with ATP.

Reversible: no

General description

A cell-permeable trisubstituted pyrazole compound that acts as a highly potent ATP-competitive inhibitor of CK1δ and p38α (IC50 = 20 and 40 nM, respectively). Shown to affect p38β, PKA, JNK2, and JNK3 activity (IC50 = 2.3, 10.5, 19.7, and 69.7 µM, respectively) only at much higher concentations and exhibit little effect against a panel of 44 other commonly studied kinases, including p38δ/γ, even at a conentraion of 10 µM or higher. An excellent tool for studying p38-mediated responses both in cells in vitro and in animals in vivo.

Other Notes

Mbalaviele, G., et al. 2006. J. Pharm. Exp. Ther.317, 1044.
Liu, Y.H., et al. 2005. J. Card. Fail.11, 74.
Yu, J.J., et al. 2003. J. Immunol.171, 6112.

Packaging

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

B

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
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