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506169 Sigma-Aldrich

InhibitorSelect p53 Pathway Regulators Panel

The InhibitorSelect p53 Pathway Regulators Panel controls the biological activity of InhibitorSelect. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

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Properties

Quality Level   100
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   -20C
solubility   DMSO: soluble (supplied)
shipped in   wet ice

Description

General description

A panel containing 18 potent, selective and cell-permeable inhibitors and 1 activator that is useful for the study of p53 pathway. The panel contains the following inhibitors/activator and 15 ml anhydrous DMSO for reconstitution:

A panel containing 18 potent, selective and cell-permeable inhibitors and 1 activator that is useful for the study of p53 pathway:2 mg of ATM Kinase Inhibitor (Cat. No. 118500),5 mg ATM/ATR Kinase Inhibitor (Cat. No. 118501),10 mg of Anacardic Acid (Cat. No. 172050),5 mg of Cdk1 Inhibitor IV, RO-3306 (Cat. No. 217699),5 mg of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710),1 mg of Chk2 Inhibitor II (Cat. No. 220486),5 mg of Hdm2 E3 Ligase Inhibitor (Cat. No. 373225),5 mg of JNK Inhibitor II (Cat. No. 420119),1 mg of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143),10 mg of MDMX Inhibitor, SJ-172550 (Cat. No. 444155),5 mg of MG-132 (Cat. No. 474790),5 mg of p21-Activated Kinase Inhibitor III, IPA-3 (Cat. No. 506106),5 mg of Pifithrin-α (Cat. No. 506132),1 mg of PI-103 (Cat. No. 528100),1 mg of PARP Inhibitor VIII, PJ34 (Cat. No. 528150),10 mg of PPM1D Phosphatase Inhibitor (Cat. No. 529578),10 mg of PRIMA-1 (Cat. No. 530050),1 mg of Caspase Inhibitor I (Cat. No. 627610),and 1 mg Trichostatin A, Streptomyces sp. (Cat. No. 647925).Also provided with 15 ml of anhydrous DMSO (Cat. No. KP31817). Supplied with a data sheet.

Packaging

1 ea in Glass bottle

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Each solutions is stable for up to 3 months at -20°C.

Please refer to information provided on the CD for reconstitution of individual inhibitors.

Other Notes

Feng, Z. and Levine, A.J., 2010. Trends Cell Biol.20, 427.
Wiman, K.G., 2010. Oncogene29, 4245.
Brown, C.J., et al. 2009. Nat. Rev. Cancer9, 862.
Dey, A., et al. 2008. Br. J. Cancer98, 4.
Levine, A.J., et al. 2006. Cell Death Differ.13, 1027.

Safety & Documentation

Safety Information

Protocols & Articles
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