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  • 513001 - InSolution PD 98059 - CAS 167869-21-8 - Calbiochem

513001 Sigma-Aldrich

InSolution PD 98059 - CAS 167869-21-8 - Calbiochem

InSolution PD 98059, CAS 167869-21-8, is a 5 mg/ml solution in DMSO. A a cell-permeable, selective & reversible inhibitor of MAP Kinase Kinase (MEK).

Synonym: InSolution PD 98059 - CAS 167869-21-8 - Calbiochem, MEK Inhibitor V

  • CAS Number 167869-21-8

  • Empirical Formula (Hill Notation) C16H13NO3

  • Molecular Weight 267.28

  •  MDL number MFCD00671789



Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, P to Q,
Quality Level   100
assay   ≥98% (HPLC)
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   -20C
shipped in   wet ice
InChI   1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3


General description

Selective and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. Pretreatment of PC-12 cells with PD 98059 completely blocks the 4-fold increase of MAP kinase activity produced by nerve growth factor (NGF; IC50 = 2 µM); however, it has no effect on NGF-dependent tyrosine phosphorylation of the pp140trk receptor or its substrate Shc and does not block NGF-dependent activation of PI 3-kinase. Inhibits cell growth and reverses the phenotype of ras-transformed BALB 3T3 mouse fibroblasts and rat kidney cells.


1 ml in Glass bottle

Biochem/physiol Actions

Cell permeable: yes

Primary Target
MAP kinase kinase (MEK)

Product does not compete with ATP.

Reversible: yes

Target IC50: 2 µM in completely blocking the 4-fold increase in MAP kinase activity produced by nerve growth factor in PC12 cells


Packaged under inert gas


Toxicity: Irritant (B)

Physical form

A 5 mg/ml solution of PD 98059 (Cat. No. 513000) in anhydrous DMSO.


Following initial thaw, aliquot and freeze.

Other Notes

Kültz, D., et al. 1998. J. Biol. Chem.273, 13645.
Dudley, D.T., et al. 1995. Proc. Natl. Acad. Sci. USA92, 7686.
Langlois, W.J., et al. 1995. J. Biol. Chem.270, 25320.
Pang, L., et al. 1995. J. Biol. Chem.270, 13585.
Waters, S.B., et al. 1995. J. Biol. Chem.270, 20883.

Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Safety Information

WGK Germany 
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