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516090-M Millipore

Penciclovir - CAS 39809-25-1 - Calbiochem

A carba analog of Ganciclovir. Active against several herpes viruses. Induces apoptosis effectively without exerting much genotoxicity.

Synonym: 2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one, Penciclovir - CAS 39809-25-1 - Calbiochem

  • CAS Number 39809-25-1

  • Empirical Formula (Hill Notation) C10H15N5O3

  • Molecular Weight 253.26

  •  MDL number MFCD15142866

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Properties

Related Categories Antibiotics, Antiviral, Biochemicals and Reagents, Spectrum of Activity
Quality Level   100
assay   ≥98% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
color   white
solubility   water: 1 mg/mL
  aqueous buffer, pH 2.0: 10 mg/mL
InChI   1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)
InChI key   JNTOCHDNEULJHD-UHFFFAOYSA-N

Description

General description

A carba analog of Ganciclovir (Cat. No. 345700). Active against several herpes viruses (IC50 = 37.9 µM for HHV-6A and 77.8 µM for HHV-6B). Induces apoptosis effectively without exerting much genotoxicity.

A synthetic acyclic guanine derivative and a carba analog of Ganciclovir (Cat. No. 345700) that is active against several herpes viruses (IC50 = 37.9 µM for HHV-6A and 77.8 µM for HHV-6B). Induces apoptosis effectively without exerting much genotoxicity.

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.

Other Notes

Leary, J.J., et al. 2002.Antimicrob. Agents Chemother.46, 762.
Amjad, M., et al. 2001. Microbiol. Immunol.45, 233.
Thust, R., et al. 2000. Cancer Gene Ther.7, 107.
Thust, R., et al. 1996. Antiviral Res.31, 105.
Shaw, T., et al. 1994. Antimicrob. Agents Chemother.38, 719.
Harnden, M.R. 1989. J. Med. Chem.32, 1738.

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