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528245 Sigma-Aldrich

PLD Inhibitor, FIPI - Calbiochem

The PLD Inhibitor, FIPI controls the biological activity of PLD. This small molecule/inhibitor is primarily used for Membrane applications.

Synonym: Compound 4k, PLD Inhibitor I, PLD Inhibitor, FIPI - Calbiochem

  • Empirical Formula (Hill Notation) C23H24FN5O2

  • Molecular Weight 421.47

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Lipids in Cell Signaling, Phospholipase Inhibitors, Phospholipid Metabolism More...
Quality Level   100
assay   ≥99% (HPLC)
form   powder
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   off-white
solubility   DMSO: 100 mg/mL
shipped in   ambient

Description

General description

A cell-permeable, PLD1/2 inhibitor (IC50 = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC50 = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic β-cells.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Su, W., et al. 2009. Mol Pharmacol75, 437.
Monovich, L., et al. 2007. Bioorg Med Chem17, 2310.

Safety & Documentation

Safety Information

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