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538925 Sigma-Aldrich

Prostaglandin I₂, Sodium Salt - CAS 61849-14-7 - Calbiochem

Potent vasodilatory prostaglandin produced by the endothelium.

Synonym: PGI₂, Prostacyclin, Prostaglandin I₂, Sodium Salt - CAS 61849-14-7 - Calbiochem

  • CAS Number 61849-14-7

  • Empirical Formula (Hill Notation) C20H31O5 · Na

  • Molecular Weight 374.45

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Properties

Quality Level   100
assay   ≥98% (HPLC)
form   crystalline solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   -20C
solubility   water: soluble
shipped in   wet ice
InChI   1S/C20H32O5.Na/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22;/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,15-8-;/t14-,16+,17+,18+,19-;/m0./s1
InChI key   LMHIPJMTZHDKEW-XQYLJSSYSA-M

Description

General description

Potent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Cytoprotective and fibrinolytic. Inhibits platelet aggregation by receptor mediated stimulation of adenylate cyclase.

Potent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Exhibits cytoprotective and fibrinolytic properties.

Packaging

1 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
Induces vasodilation

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). This product is rapidly hydrolyzed in acidic solutions. The half-life at pH 7.48 is between 3.5 min and 10.5 min at 25°C. At pH 12 the half-life is ~6 days at 25°C. No loss of biological activity was observed at pH 9.37 for 48 h, when stored at 0°C.

Other Notes

Vane, J.R. 1985. Adv. Prostaglandin Thromboxane Leukotriene Res.15, 11.
Moncada, S., et al. 1979. Pharmacol. Rev.30, 293.
Cho, M.J. and Allen, M.A. 1978. Prostaglandins15, 943.
Tateson, J.E., et al. 1977. Prostaglandins13, 389.

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