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551850 Sigma-Aldrich

Quinacrine dihydrochloride

A non-specific phospholipase A2 (PLA2) inhibitor.

Synonym: 6-Chloro-9-(4-diethylamino-1-methylbutylamino)-2-methoxyacridine dihydrochloride, Atebrin dihydrochloride, Mepacrine dihydrochloride, Mepacrine

  • CAS Number 69-05-6

  • Empirical Formula (Hill Notation) C23H30ClN3O · 2HCl

  • Molecular Weight 472.88

  •  Beilstein/REAXYS Number 4834013

  •  MDL number MFCD00012659

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Properties

Quality Level   100
assay   ≥98% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   +15C to +30C
color   yellow
solubility   water: soluble
shipped in   ambient
SMILES string   Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13
InChI   1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
InChI key   UDKVBVICMUEIKS-UHFFFAOYSA-N

Description

General description

A non-specific phospholipase A2 (PLA2) inhibitor. Acts as an acetylcholine receptor antagonist. Suppresses glibenclamide-sensitive K+-currents (IC50 = 4.4 µM). Also inhibits monoamine oxidase (MAO).

Phospholipase A2 (PLA2) inhibitor. Acts as an acetylcholine antagonist. Suppresses glibenclamide-sensitive K+-currents (IC50 = 4.4 µM). Also inhibits monoamide oxidase (MAO).

Packaging

100 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Non-selective MAO-A/B inhibitor.

Product does not compete with ATP.

Reversible: no

Target IC50: 4.4 µM in suppressing glibenclamide-sensitive K+-currents

Warning

Toxicity: Harmful (C)

Reconstitution

Stock solutions are stable for up to 60 h at 20°C.

Other Notes

Holscher, C. 1995. Neurobiol. Learn. Mem. 63, 206.
Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117.
Sargent, C.A., et al 1992. J. Pharmacol. Exp. Ther.262, 1161.
Voorhis, B.J., et al. 1992. Invertebr. Reprod. Dev.21, 33.
Murakami, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 714.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
WGK Germany 
WGK 3
Protocols & Articles
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