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Ribavirin - CAS 36791-04-5 - Calbiochem

A non-interferon-inducing, broad spectrum antiviral nucleoside. Reported to be active against RSV, HIV, HCV, and other infectious agents. Its metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase.

Synonym: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide, Virazole, Ribavirin - CAS 36791-04-5 - Calbiochem

  • CAS Number 36791-04-5

  • Empirical Formula (Hill Notation) C8H12N4O5

  • Molecular Weight 244.20

  •  MDL number MFCD00058564

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Properties

Related Categories Antibiotics, Antiviral, Biochemicals and Reagents, Spectrum of Activity
Quality Level   100
assay   ≥99% (HPLC)
  ≥99% (TLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   +15C to +30C
color   white
solubility   water: 20 mg/mL
  DMSO: soluble
shipped in   ambient
InChI   1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
InChI key   IWUCXVSUMQZMFG-AFCXAGJDSA-N

Description

General description

A non-interferon-inducing, broad spectrum antiviral nucleoside that is active against RSV, HIV, HCV and other infectious agents. Inhibits the growth of human myeloma 8226 cells (IC50 = 40 µM) and ovarian carcinoma OVCAR-5 cells (IC50 = 35 µM). Its metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase. Antiviral effects of Ribavirin can be reversed by depriving infected cells of methionine or isoleucine.

A non-interferon-inducing, broad spectrum antiviral nucleoside. Reported to be active against RSV, HIV, HCV, and other infectious agents. Its metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase.

Packaging

10 mg in Glass bottle

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Other Notes

Li, W., et al. 1999. Oncol. Res.11, 243.
Honda, Y., et al. 1994. Antimicrob. Agents Chemother.38, 653.
Liao, H.J. and Stollar, V. 1993. Antiviral Res. 22, 285.
Kakumu, S., et al. 1993. Gastroenterology105, 507.
Sidwell, R.W., et al. 1979. Pharmacol. Ther.6, 123.

Safety & Documentation

Safety Information

Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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