• USA Home
  • 559395 - SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem

EMAIL THIS PAGE TO A FRIEND
559395 Sigma-Aldrich

SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem

SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).

Synonym: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor XVI, Hydrochloride, SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem

  • CAS Number 869185-85-3

  • Empirical Formula (Hill Notation) C21H16FN3OS · xHCl

  • Molecular Weight 377.43 (free base basis)

Purchase

Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, L to O,
Quality Level   100
assay   ≥95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   -20C
color   bright yellow
solubility   water: 10 mg/mL
  DMSO: soluble
shipped in   ambient

Description

General description

A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).

A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).

Packaging

1, 10 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
p38 MAP kinase

Product does not compete with ATP.

Reversible: no

Target IC50: 34 nM against p38 MAP kinase in vitro, 600 nM in cells; 50-100 nM against IL-1 and TNF-a production from LPS-stimulated human monocytes and the human monocyte cell line THP-1; 0.2-1.0 µM against platelet aggregation caused by collagen

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?