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567630 Sigma-Aldrich

Sodium Salicylate - CAS 54-21-7 - Calbiochem

A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein.

Synonym: Salicylic Acid, Na, NaSal, Sodium Salicylate - CAS 54-21-7 - Calbiochem

  • CAS Number 54-21-7

  • Empirical Formula (Hill Notation) C7H5O3 · Na

  • Molecular Weight 160.10

  •  MDL number MFCD00002440

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Properties

Related Categories A to C, Biochemicals and Reagents, Cyclooxygenase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
assay   ≥98% (titration)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   +15C to +30C
color   off-white
solubility   water: 50 mg/mL
  ethanol: soluble
shipped in   ambient
InChI   1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
InChI key   ABBQHOQBGMUPJH-UHFFFAOYSA-M

Description

General description

A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.

A non-steroidal, anti-inflammatory drug that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.

Packaging

5 g in Glass bottle

Biochem/physiol Actions

Cell permeable: yes

Primary Target
TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Schwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Flash Point(F) 
208.9 °F - Pensky-Martens closed cup
Flash Point(C) 
98.3 °C - Pensky-Martens closed cup
Protocols & Articles
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