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568500 Sigma-Aldrich

SQ 22536 - CAS 17318-31-9 - Calbiochem

Cell-permeable adenylate cyclase inhibitor.

Synonym: 9-(Tetrahydro-2ʹ-furyl)adenine, SQ 22536 - CAS 17318-31-9 - Calbiochem

  • CAS Number 17318-31-9

  • Empirical Formula (Hill Notation) C9H11N5O

  • Molecular Weight 205.22

  •  MDL number MFCD00210216

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Properties

Related Categories A to C, Adenylate cyclase, Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   +2C to +8C
color   off-white
solubility   DMSO: 25 mg/mL
  water: 5 mg/mL
shipped in   ambient
storage temp.   room temp
InChI   1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12)
InChI key   UKHMZCMKHPHFOT-UHFFFAOYSA-N

Description

General description

Cell-permeable adenylate cyclase inhibitor. Blocks PTH-stimulation of adenylate cyclase (IC50 = 200 µM). Reduces PGE2-induced inhibition of O2· production.

Packaging

5 mg in Glass bottle

Biochem/physiol Actions

Cell permeable: yes

Primary Target
adenylate cyclase

Product does not compete with ATP.

Reversible: no

Target IC50: 200 µM against adenylate cyclase

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.

Other Notes

Talpain, E., et al. 1995. Br. J. Pharmacol. 114, 1459.
Tamaoki, J., et al. 1993. Prostaglandins45, 363.
Fabbri, E., et al. 1991. J. Enzyme Inhib.5, 87.
Goldsmith, B.A. and Abrams, T.W. 1991. Proc. Natl. Acad. Sci. USA 88, 9021.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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