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  • 569396 - InSolution Staurosporine, Streptomyces sp.

569396 Sigma-Aldrich

InSolution Staurosporine, Streptomyces sp.

InSolution Staurosporine, Streptomyces sp. CAS 62996-74-1, is provided as a 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569397) in DMSO

Synonym: InSolution Staurosporine, Streptomyces sp., PKA Inhibitor II, MLCK Inhibitor I

  • CAS Number 62996-74-1

  • Empirical Formula (Hill Notation) C28H26N4O3

  • Molecular Weight 466.53

  •  MDL number MFCD00077402



Related Categories Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Protein Kinase A (PKA), Serine/Threonine Kinase Biology,
Quality Level   100
assay   ≥97% (HPLC)
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   = -70C
shipped in   wet ice
InChI   1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1


General description

A potent, cell-permeable broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.


100 μg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target

Product competes with ATP.

Reversible: yes

Target IC50: 7 nM, 20 nM, 1.3 nM, 700 pM, 8.5 nM, against protein kinase A , CaM kinase, myosin light chain kinase, protein kinase C, and protein kinase G, respectively


Packaged under inert gas


Toxicity: Irritant (B)

Physical form

A 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569397) in DMSO.


Following initial thaw, aliquot, purge with inert gas, and freeze (-70°C).

Other Notes

Couldwell, W.T., et al. 1994. FEBS Lett.345, 43.
Nishimura, H. and Simpson, I.A. 1994. Biochem. J.302, 271.
Bruno, S., et al. 1992. Cancer Res.52, 470.
Kiss, Z. and Deli, E. 1992. Biochem. J.288, 853.
Vitale, M.L., et al. 1992. Neuroscience51, 463.
Hoffman, R. and Newland, E.S. 1991. Cancer Chemotherap. Pharmacol.28, 102.
Oka, S., et al. 1986. Agric. Biol. Chem.50, 2723.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

WGK Germany 
Flash Point(F) 
188.6 °F - (Dimethylsulfoxide)
Flash Point(C) 
87 °C - (Dimethylsulfoxide)
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