• USA Home
  • 574714 - Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem

EMAIL THIS PAGE TO A FRIEND
574714 Millipore

Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem

The Syk Inhibitor IV, BAY 61-3606, also referenced under CAS 732938-37-8, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: 2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606, Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem

  • CAS Number 732983-37-8

  • Empirical Formula (Hill Notation) C20H18N6O3 · xHCl · yH2O

  • Molecular Weight 390.40 (anhydrous free base basis)

Purchase

Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, P to Q,
Quality Level   100
assay   ≥97% (HPLC)
form   solid
potency   10 nM IC50
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated (hygroscopic)
  protect from light
storage conditions   +2C to +8C
color   yellow
solubility   DMSO: 10 mg/mL
  water: 20 mg/mL
shipped in   ambient

Description

General description

A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.

Packaging

2 mg in Glass bottle

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Syk

Product competes with ATP.

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther.306, 1174.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?