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581004 Sigma-Aldrich

Telomerase Inhibitor III, Sodium Salt - Calbiochem

The Telomerase Inhibitor III, Sodium Salt controls the biological activity of Telomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym: TAG-6, 5ʹ-d(TTAGGG)-3ʹ

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Properties

Quality Level   100
form   lyophilized
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   = -70C
solubility   water: soluble
shipped in   wet ice

Description

General description

A short, cell-permeable hexameric phosphorothioate oligonucleotide (PS-ODN) telomer mimic that inhibits telomerase activity in cell lysates and lengthens cell doubling time in vitro and in vivo at concentrations of less than 2.5 µM.

A short, cell-permeable hexameric phosphorothioate oligonucleotide (PS-ODN) telomere mimic that inhibits telomerase activity in cell lysates and lengthens cell doubling time in vitro and in vivo at concentrations of less than 2.5 µM. Note: 150 nmol = 285 µg.

M.W. ~1900.

Packaging

150 nmol in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Telomerase activity in cell lysates

Product competes with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Sequence

5′-d(TTAGGG)-3′

Other Notes

Mata, J.E., et al. 1997. Toxicol. Appl. Pharmacol. 144, 189.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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