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581500 Sigma-Aldrich

TEMPOL - CAS 2226-96-2 - Calbiochem

A stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap.

Synonym: 4-Hydroxy-TEMPO, 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl, TEMPOL - CAS 2226-96-2 - Calbiochem

  • CAS Number 2226-96-2

  • Empirical Formula (Hill Notation) C9H18NO2

  • Molecular Weight 172.24

  •  MDL number MFCD00006478

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Properties

Related Categories Antioxidant and Free Radical Scavengers, Cancer Research, Cell Biology, Chemopreventive Agents
Quality Level   100
assay   ≥97% total nitrogen (N) basis
form   crystals
  powder
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   -20C
color   orange
solubility   DMSO: 5 mg/mL
  ethanol: soluble
  water: soluble
shipped in   ambient
storage temp.   room temp
InChI   1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3
InChI key   UZFMOKQJFYMBGY-UHFFFAOYSA-N

Description

General description

A stable, cell-permeable nitroxide free radical that acts as a radical scavenger and nitric oxide spin trap. Induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. Reported to reduce organ injury following hemorrhagic shock. Exhibits radio-protective and anti-proliferative properties.

A stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. Reported to reduce organ injury following hemorrhagic shock. Exhibits radio-protective and anti-proliferative properties.

Packaging

500 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Free radical scavenger and nitric oxide spin trap

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Reconstitution

Prepare fresh solutions. Following reconstitution, aliquot and freeze (-20°C).

Other Notes

Gariboldi, M.B., et al. 2000. Free Radic. Biol. Med.29, 633.
Miura, Y., et al. 2000. J. Radiat. Res. (Tokyo)41, 103.
Mota-Filipe, H., et al. 1999. Shock 12, 255.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
WGK Germany 
WGK 1
Flash Point(F) 
294.8 °F - DIN 51758
Flash Point(C) 
146 °C - DIN 51758
Protocols & Articles
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