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584223 Sigma-Aldrich

InSolution Tetrahydrouridine - CAS 18771-50-1 - Calbiochem

Tetrahydrouridine is a potent competitive inhibitor of cytidine deaminase.

Synonym: InSolution Tetrahydrouridine - CAS 18771-50-1 - Calbiochem, THU, H4U, 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one, dihydrate

  • CAS Number 18771-50-1

  • Empirical Formula (Hill Notation) C9H16N2O6 · 2H2O

  • Molecular Weight 284.26

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Properties

Quality Level   100
assay   ≥90% (TLC)
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  avoid repeated freeze/thaw cycles
  protect from light
storage conditions   = -70C
shipped in   ambient
InChI   1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1
InChI key   UCKYOOZPSJFJIZ-XVKVHKPRSA-N

Description

General description

A potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. The solid form of this compound (Cat. No. 584222) is also available.

Packaging

25 mg in Glass bottle

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cytidine deaminase

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical form

A 100 mM (25 mg/879 µL) solution of Tetrahydrouridine (Cat. No. 584222) in H₂O.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Other Notes

Yusa, K., et al. 1995. Biochem. Biophys. Res. Commun.206, 486.

Bouffard, D.Y., et al. 1993. Biochem Pharmacol.45, 1857.
Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol.30, 7.
Riva, C., et al. 1992. Chemotherapy38, 358.
Yusa, K., et al. 1992. J. Biol. Chem.267, 16848.
Hanze, A.R. 1967. J. Am. Chem. Soc.89, 6720.

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