• USA Home
  • 612084 - TIMP-2, Human Rheumatoid Synovial Fibroblast - Calbiochem

EMAIL THIS PAGE TO A FRIEND
612084 Sigma-Aldrich

TIMP-2, Human Rheumatoid Synovial Fibroblast - Calbiochem

Native TIMP-2 from human rheumatoid synovial fibroblast.

Synonym: Tissue Inhibitor of Metalloproteinase-2

Purchase

Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Enzymes, Inhibitors, and Substrates, Matrix Metalloproteinases Products,
Quality Level   100
assay   ≥90% (SDS-PAGE)
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  avoid repeated freeze/thaw cycles
storage conditions   = -70C
shipped in   wet ice

Description

General description

Native TIMP-2 from human rheumatoid synovial fibroblast. Member of a family of inhibitors that participate in the activation and regulation of MMP activity. Forms a non-covalent stoichiometric complex with latent and active MMPs. Shown to inhibit the activities of MMP-1, MMP-2, MMP-12, and transin.

Packaging

5 μg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
MMP-1

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Physical form

In 200 mM NaCl, 50 mM Tris-HCl, 5 mM CaCl₂, 1 µM ZnCl₂, 0.05% BRIJ® 35 Detergent, pH 7.0.

Preparation Note

Prepared from fibroblasts that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Other Notes

Greene, J., et al. 1996. J. Biol. Chem. 271, 30375.
Miyazaki, K., et al. 1993. J. Biol. Chem. 268, 14387.

Legal Information

Brij is a registered trademark of Croda International PLC

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?