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  • 612084 - TIMP-2, Human Rheumatoid Synovial Fibroblast - Calbiochem

612084 Sigma-Aldrich

TIMP-2, Human Rheumatoid Synovial Fibroblast - Calbiochem

Native TIMP-2 from human rheumatoid synovial fibroblast.

Synonym: Tissue Inhibitor of Metalloproteinase-2



Related Categories Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Enzymes, Inhibitors, and Substrates, Matrix Metalloproteinases Products,
Quality Level   100
assay   ≥90% (SDS-PAGE)
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  avoid repeated freeze/thaw cycles
storage conditions   = -70C
shipped in   wet ice


General description

Native TIMP-2 from human rheumatoid synovial fibroblast. Member of a family of inhibitors that participate in the activation and regulation of MMP activity. Forms a non-covalent stoichiometric complex with latent and active MMPs. Shown to inhibit the activities of MMP-1, MMP-2, MMP-12, and transin.


5 μg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target

Product does not compete with ATP.

Reversible: no


Toxicity: Standard Handling (A)

Physical form

In 200 mM NaCl, 50 mM Tris-HCl, 5 mM CaCl₂, 1 µM ZnCl₂, 0.05% BRIJ® 35 Detergent, pH 7.0.

Preparation Note

Prepared from fibroblasts that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Other Notes

Greene, J., et al. 1996. J. Biol. Chem. 271, 30375.
Miyazaki, K., et al. 1993. J. Biol. Chem. 268, 14387.

Legal Information

Brij is a registered trademark of Croda International PLC

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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