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614310 Sigma-Aldrich

TLR3/dsRNA Complex Inhibitor - Calbiochem

The TLR3/dsRNA Complex Inhibitor blocks dsRNA binding to TLR3.

Synonym: ( R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor, (R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor, TLR3/dsRNA Complex Inhibitor - Calbiochem

  • Empirical Formula (Hill Notation) C18H13ClFNO3S

  • Molecular Weight 377.82

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Properties

Quality Level   100
assay   ≥99% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   white
solubility   DMSO: 50 mg/mL
shipped in   wet ice

Description

General description

A thiophenecarboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki = 2.96 µM; Kd = 19 nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-α and IL-1β (IC90 = 27 µM) and NO production (IC50 = 3.44 µM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50 >> 100 µM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays).

Packaging

10 mg in Glass bottle

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Cheng, K., et al. 2011. J. Am. Chem. Soc.133, 3764.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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