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614350 Sigma-Aldrich

Tomatidine, HCl - CAS 6192-62-7 - Calbiochem

A steroidal alkaloid that structurally resembles Cyclopamine, but lacks the capacity to inhibit Shh (Sonic Hedgehog) signaling. Reported to be non-teratogenic.

Synonym: Tomatidine, HCl - CAS 6192-62-7 - Calbiochem

  • CAS Number 6192-62-7

  • Empirical Formula (Hill Notation) C27H45NO2 · xHCl

  • Molecular Weight 415.65 (free base basis)

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Properties

assay   ≥90% (TLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
color   off-white
solubility   DMF: 2 mg/mL
  DMSO: 2 mg/mL
  ethanol: 2.5 mg/mL
  chloroform: methanol (1:1): 50 mg/mL
shipped in   ambient
storage conditions   +2C to +8C

Description

General description

A steroidal alkaloid that structurally resembles Cyclopamine (Cat. No. 239803), but lacks the capacity to inhibit Sonic Hedgehog (Shh) signaling. Reported to be non-teratogenic. Useful as a negative control.

A steroidal alkaloid that structurally resembles Cyclopamine (Cat. No. 239803), but lacks the capacity to inhibit Shh (Sonic Hedgehog) signaling. Reported to be non-teratogenic.

Packaging

25 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
Negative control for Shh (Sonic Hedgehog) signaling

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Preparation Note

Slight warming may be required to achieve complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Berman, D.M., et al. 2003. Nature,425, 846.
Thayer, S.P., et al. 2003. Nature,425, 851.
Watkins, D.N., et al. 2003. Nature422, 313.
Cooper, M.K., et al. 1998. Science280, 1603.
Kim, S.K. and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA95, 13036.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis (COA)

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