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648480 Sigma-Aldrich

Troponin I, Human Heart

Synonym: Troponin I, Human Heart, hcTnI

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Properties

Related Categories Auxiliary Proteins, Biochemicals and Reagents, Other, Proteins and Derivatives
Quality Level   100
assay   ≥95% (SDS-PAGE)
form   lyophilized
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
solubility   urea/Tris buffer (0.02 M Tris, HCl, pH 7.5, 7 M urea, 5 mM EDTA, 15 mM 2-mercaptoethanol): 1 mg/mL
shipped in   ambient

Description

General description

Native troponin I purified from human heart. Inhibitory subunit of troponin that binds to actin in the absence of Ca2+, thus inhibiting the ATPase activity of actomyosin. Presence of Tnl in plasma has been used for early detection of myocardial infarction. Useful as a standard in immunoassay and as an immunogen for anti-sera production. Also useful as a tracer for iodination.

Native troponin I purified from human heart. Inhibitory subunit of troponin that binds to actin in the absence of Ca2+, thus inhibiting the ATPase activity of actomyosin. Presence of hcTnI in plasma has been used for early detection of myocardial infarction. Useful as a standard in immunoassay and as an immunogen for antisera production. Also useful as a tracer for iodination.

Packaging

100 μg in Glass bottle

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from 10 mM HCl.

Preparation Note

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Falahati, A., et al. 1999. Am. Heart J. 137, 332.
Mangano, D.T. 1994. Anesthesiology 81, 1317.

Safety & Documentation

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