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TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem

The TrpA1 Antagonist, HC-030031, also referenced under CAS 349085-38-7, controls the biological activity of TrpA1. This small molecule/inhibitor is primarily used for Neuroscience applications.

Synonym: HC-030031, TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem

  • CAS Number 349085-38-7

  • Empirical Formula (Hill Notation) C18H21N5O3

  • Molecular Weight 355.39

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Properties

Related Categories Antagonists, Calcium Channel Modulators, Cell Biology, Cell Signaling and Neuroscience, Endothelins,
assay   ≥98% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   white
solubility   DMSO: 50 mg/mL, clear, colorless

Description

General description

A cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.

Warning

Toxicity: Standard Handling (A)

Other Notes

Taylor-Clark, T., et al. 2008. Mol. Pharmacol.73, 274.
McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A.104, 13525.

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