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654257 Sigma-Aldrich

TNF-α Antagonist III, R-7050 - CAS 303997-35-5 - Calbiochem

The TNF-α Antagonist III, R-7050, also referenced under CAS 303997-35-5, controls the biological activity of TNF-α.

Synonym: 8-Chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline, TNF-α Antagonist III, R-7050 - CAS 303997-35-5 - Calbiochem

  • CAS Number 303997-35-5

  • Empirical Formula (Hill Notation) C16H8ClF3N4S

  • Molecular Weight 380.77

  •  MDL number MFCD00140737

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Properties

Quality Level   100
assay   ≥97% (HPLC)
form   powder
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   light yellow
solubility   DMSO: 5 mg/mL
shipped in   ambient

Description

General description

A cell-permeable triazoloquinoxaline compound that acts as a TNF-α receptor antagonist via the blockage of receptor-adaptor molecules complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding. Shown to selectively inhibit TNF-α-, but not Fas- or C6-ceramide-, induced caspase activation and cell death in ME180 cells and exhibit higher potency against TNF-α-induced than IL-1β-induced NF-κB activation (EC50 = 0.631 and 1.45 µM, respectively) in A549 cells.

Packaging

10 mg in Plastic ampoule

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Gururaja, T.L., et al. 2007. Chem. Biol.14, 1105.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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