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654380 Sigma-Aldrich

Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem

Tunicamycin, Streptomyces lysosuperficus, CAS 11089-65-9, is a nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages.

Synonym: Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem

  • CAS Number 11089-65-9

  • Empirical Formula (Hill Notation) C39H64N4O16

  • Molecular Weight 844.94

  •  MDL number MFCD00065709

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Properties

Quality Level   200
assay   ≥98% (A+B+C+D, HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   +15C to +30C
color   white to off-white
solubility   DMSO: 10 mg/mL
  DMF: soluble
  pyridine: soluble
shipped in   ambient
InChI   1S/C30H46N4O16/c1-11(2)5-4-6-16(38)32-19-23(43)20(40)14(47-29(19)50-28-18(31-12(3)36)22(42)21(41)15(10-35)48-28)9-13(37)26-24(44)25(45)27(49-26)34-8-7-17(39)33-30(34)46/h4,6-8,11,13-15,18-29,35,37,40-45H,5,9-10H2,1-3H3,(H,31,36)(H,32,38)(H,33,39,46)/b6-4+/t13?,14-,15-,18-,19-,20+,21-,22-,23-,24+,25-,26-,27-,28-,29-/m1/s1
InChI key   ZHSGGJXRNHWHRS-PEALBESXSA-N

Description

General description

A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells. Also available as a 25 mM solution in DMSO (Cat. No. 504570).

A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells.

Packaging

10 mg in Glass bottle

50 mg in Alu drum

Biochem/physiol Actions

Primary Target
N-linked glycosylation

Secondary Target
thrombin-induced Ca2+ mobilization in cells

Warning

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Preparation Note

Aqueous solutions can be prepared from DMSO stock solutions by diluting in H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0.

Reconstitution

Aqueous solutions can be prepared from stock solutions in DMSO by diluting with H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0 (preferably >8.0).

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Tordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
Price, B.D., et al. 1992. J. Cell Physiol.152, 545.

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