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681625 Sigma-Aldrich

W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 240 µM).

Synonym: N-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl, W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem

  • CAS Number 61714-25-8

  • Empirical Formula (Hill Notation) C16H22N2O2S · xHCl

  • Molecular Weight 306.42 (free base basis)

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology,
Quality Level   100
assay   ≥98% (NMR)
form   crystalline solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   +2C to +8C
solubility   DMSO: soluble
  water: soluble
shipped in   ambient

Description

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM) and myosin light chain kinase (IC50 = 230 µM).

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM).

Packaging

1 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Product does not compete with ATP.

Reversible: yes

Target IC50: 230 &microM and 240 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.

Warning

Toxicity: Standard Handling (A)

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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