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681629 Sigma-Aldrich

W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 51 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 28 µM).

Synonym: N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide, HCl, W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem

  • CAS Number 61714-27-0

  • Empirical Formula (Hill Notation) C16H21ClN2O2S · xHCl

  • Molecular Weight 340.87 (free base basis)

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology,
Quality Level   100
assay   ≥98% (TLC)
form   crystalline solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   +2C to +8C
color   off-white
solubility   DMSO: 5 mg/mL
  DMF: soluble
  warm ethanol: soluble
shipped in   ambient

Description

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM) and myosin light chain kinase (IC50 = 51 µM).

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM).

Packaging

10 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Myosin light chain kinase

Product does not compete with ATP.

Reversible: yes

Target IC50: 51 µM inhibiting myosin light chain kinase; 28 µM inhibiting Ca2+-calmodulin-dependent phosphodiesterase

Warning

Toxicity: Standard Handling (A)

Other Notes

Caulfield, M.P., et al. 1991. Neurosci. Lett.125, 57.
Asano, M. 1989. J. Pharmacol. Exp. Ther.251, 764.
Itoh, H., and Hidaka, H. 1984. J. Biochem.96, 1721.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Hidaka, H. 1981. Proc. Natl. Acad. Sci. USA 78, 4354.

Safety & Documentation

Safety Information

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