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681635 Sigma-Aldrich

W-12, Hydrochloride - CAS 89108-46-3 - Calbiochem

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 300 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 260 µM).

Synonym: N-(4-Aminobutyl)-2-naphthalenesulfonamide, HCl, W-12, Hydrochloride - CAS 89108-46-3 - Calbiochem

  • CAS Number 89108-46-3

  • Empirical Formula (Hill Notation) C14H18N2O2S · xHCl

  • Molecular Weight 278.37 (free base basis)

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology,
Quality Level   100
assay   ≥97% (TLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   -20C
color   white
solubility   water: 1 mg/mL
  ethanol: 5 mg/mL
shipped in   ambient

Description

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 260 µM) and myosin light chain kinase (IC50 = 300 µM).

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 300 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 260 µM).

Packaging

1 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Myosin light chain kinase (Mlck)

Product does not compete with ATP.

Reversible: yes

Target IC50: 300 µM and 260 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Tanaka, T., et al. 1983. Pharmacol.26, 249.
Asano, M., et al. 1982. J. Pharmacol. Exp. Ther.220, 191.
Hidaka, H. 1981. Prot. Nuc. Acid Enz.26, 977.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem.255, 11078.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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