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681636-M Millipore

W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).

Synonym: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl, W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem

  • CAS Number 88519-57-7

  • Empirical Formula (Hill Notation) C14H17ClN2O2S · xHCl

  • Molecular Weight 312.81 (free base basis)

  •  MDL number MFCD00058030

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology,
assay   ≥98% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   +2C to +8C
color   white
solubility   water: 35 mg/mL

Description

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM) and myosin light chain kinase (IC50 = 58 µM).

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM).

Biochem/physiol Actions

Target IC50: 58 µM, 68 µM, against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase

Warning

Toxicity: Standard Handling (A)

Analysis Note

single spot by TLC

Other Notes

Hidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

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