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  • 8.52090 - Fmoc-Tyr(PO(NMe₂)₂)-OH

8.52090 EMD Millipore


Fmoc-Tyr(PO(NMe₂)₂)-OH Novabiochem®. CAS 172611-23-3, molar mass 537.55 g/mol., Novabiochem®

Synonym: N-α-Fmoc-O-(bis-dimethylamino-phosphono)-L-tyrosine

  • CAS Number 172611-23-3

  • Linear Formula C₂₈H₃₂N₃O₆P

  • Molecular Weight 537.55 g/mol



Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry | Peptide Synthesis, Tyrosine More...
brand family   Novabiochem
packaging   1 g in Glass bottle (8520900001)
  5 g in Plastic bottle (8520900005)
storage temp.   Store at -15°C to -25°C.
specifications   Color (visual): white to slight yellow to beige
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Enantiomeric purity: ≥ 99.5 % (a/a)
  Purity (TLC(0811)): ≥ 98 %
  Assay (HPLC, area%): ≥ 96.0 % (a/a)
  Solubility (1 mmole in 2 ml DMF): clearly soluble
  Assay (acidimetric): ≥ 93.0 %
  Water (K. F.): ≤ 4.5 %
  Ethyl acetate (HS-GC): ≤ 0.5 %
  Acetate (IC): ≤ 0.1 %
  For TLC-Systems see our General Catalog


Background information

Fmoc-Tyr(PO(NMe2)2)-OH is a useful derivative for the synthesis of phosphotyrosine-containing peptides by Fmoc SPPS [1]. As the side-chain phosphate group is fully protected, this derivative is compatible with all coupling methods.

Regeneration of phosphotyrosine from the phosphodiamidate is effected by acid catalyzed hydrolysis using 90% aq. TFA.

The product number for this product was previously 04-12-1205.

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Safety & Documentation

Safety Information

HS Code 
2924 29 70
Storage class 
10 - 13 Other liquids and solids
WGK 2 obviously hazardous to water
Protocols & Articles
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