8.52095 Sigma-Aldrich



Synonym: Fmoc-Lys(Mca)-OH, N-α-Fmoc-N-ε-7-methoxycoumarin-4-acetyl-L-lysine

  • CAS Number 386213-32-7

  • Empirical Formula (Hill Notation) C33H32N2O8

  • Molecular Weight 584.62



Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Lysine, Peptide Synthesis and Peptide Chemistry More...
Quality Level   200
assay   ≥97% (TLC)
  ≥97.0% (HPLC)
form   powder
mfr. no.   Novabiochem®
application(s)   peptide synthesis: suitable
functional group   Fmoc
storage conditions   Store at -15°C to -25°C.


General description

A modified lysine derivative for the preparation of fluorogenically-labeled peptides by Fmoc chemistry [1].

The Mca group fluoresces at 405 nm when stimulated at 340 nm, and is most commonly used in conjunction with Dabcyl and 2,4-dinitrophenyl quenching groups.

Recently, Fmoc-Lys(Mca)-OH has been used to prepare lanthanide-based luminescent proteins by native chemical ligation [2]. Lys(Mca) was found to be stable to HF cleavage conditions used to synthesize the thioester fragments needed for ligation.

The product number for this product was previously 04-12-1233.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.


Replaces: 04-12-1233

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(011A)): ≥ 97 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Water (K. F.): ≤ 2.0 %
For TLC-Systems see our General Catalog

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles


Solvent Systems for Thin-layer Chromatography of Novabiochem Products

The table below lists the solvent systems used for the thin-layer chromatography (TLC) assay of Novabiochem products. To determine the system used, just look up the solvent system code printed adjace...
Keywords: Chromatography, Solvents, Thin layer chromatography

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