8.52373 Sigma-Aldrich



Synonym: Fmoc-Cys(STmp)-OH, N-α-Fmoc-S-2,4,6-trimethoxyphenylthio-L-cysteine

  • CAS Number 1403834-74-1

  • Empirical Formula (Hill Notation) C27H27NO7S2

  • Molecular Weight 541.64



Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Cysteine/Cystine, Peptide Synthesis and Peptide Chemistry More...
Quality Level   200
mfr. no.   Novabiochem®
storage conditions   Store at -15°C to -25°C.


General description

Fmoc-Cys(STmp)-OH [1] is a novel new tool for the regioselective synthesis of multiple disulfide bridged peptides. The STmp group is stable to piperidine but is extremely easy to remove by mild thiolysis. Albericio [2] has reported removing four STmp groups on the solid phase with only three 5 minute treatments of 0.1 M N-methylmorpholine (NMM) in DMF containing 5% DTT.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles


Selecting Orthogonal Building Blocks

Novabiochem® product range has one of the largest collections of orthogonally and quasi-orthogonally protected tri-functional amino acids. These derivatives are useful tools for the synthesis of cycl...
Keywords: Acylations, Catalysis, Combinatorial synthesis, Cyclizations, Eliminations, Filtration, High performance liquid chromatography, Peptide synthesis, Reductions, Solid phase peptide synthesis, Thiolysis

Solvent Systems for Thin-layer Chromatography of Novabiochem Products

The table below lists the solvent systems used for the thin-layer chromatography (TLC) assay of Novabiochem products. To determine the system used, just look up the solvent system code printed adjace...
Keywords: Chromatography, Solvents, Thin layer chromatography

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