GF032 Sigma-Aldrich

Neurotrophin 4/5

The Neurotrophin-4 protein (or NT-4/NT-5 protein) is a potent neurotrophic factor which supports the growth & survivability of nerve and/or glial cells.

Synonym: NT4/5

  •  eCl@ss 32160405

  •  NACRES NA.75



Quality Level   100
biological source   human
assay   >98% (SDS-PAGE and HPLC)
mfr. no.   Chemicon®
impurities   <0.1 ng/mg Endotoxin (of NT-4; 1EU/mg)
NCBI accession no.   NM_006179.3
UniProt accession no.   P34130
shipped in   dry ice


General description

Neurotrophin-4 (NT-4/NT-5) is a potent neurotrophic factor which supports the growth and survivability of nerve and/or glial cells. The active form of human NT-4 is a dimer, formed by two identical 130 amino acid subunits, which is held together by strong hydrophobic interactions.

Product Source: Human NT4/5 expressed in E.coli


Concentration range for most in vitro applications is 0.5 to 100 ng/mL. Responding cells include (partial list): Nerve, glial cells.

Storage and Stability

The lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C for up to 12 months after date of receipt. After a quick spin, reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other aqueous buffers. Reconstitute NT-4 should be stored in undiluted aliquots at -20°C for up to six months.

Analysis Note

Specific Activity: Chemicon′s human NT-4 is fully biologically active when compared to standards. The ED(50) as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cultures.

Safety & Documentation

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