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  • GF167 - BMP-4 Protein, Human Recombinant

GF167 Sigma-Aldrich

BMP-4 Protein, Human Recombinant

The Bone morphogenetic protein 4 (or BMP-4 protein) is a TGFβ superfamily ligand that is widely expressed from early embryogenesis through adulthood.

Synonym: BMP4, Bone morphogentic protein-4, DVR-4

  •  eCl@ss 32160405



Quality Level   100
assay   >97% (SDS-PAGE and HPLC)
impurities   <0.1 μg/mg protein endotoxin (<1EU/μg)
NCBI accession no.   NM_001202.3
UniProt accession no.   P12644
shipped in   dry ice


General description

Bone morphogentic protein 4 (BMP-4) is a TGFβ superfamily ligand that is widely expressed from early embryogenesis through adulthood. It plays an important role in mesenchyme formation, epidermal determination, suppression of neural induction, the development of multiple organs, and tissue repair. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein.

Product Source: Hela Cells


Cross Reactivty


Research Category
Stem Cell Research

Research Sub Category
Growth Factors & Receptors


Bioactivity assay: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.

Physical form

Product is filtered through a 0.2 micron filter before lyophilization.

Storage and Stability

Store at -20°C for up to 6 months from date of receipt.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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