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GF176 Sigma-Aldrich

TGF-β-III Protein, Human Recombinant

TGF-β-III (transforming growth factor beta III) is one of three closely related mammalian members of the large TGF-β superfamily.

Synonym: Transforming Growth Factor Beta 3, TGF-Beta-3, TGF-Beta-III

  •  eCl@ss 32160405

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Properties

Quality Level   100
assay   >98% (SDS-PAGE and HPLC)
impurities   <0.1 μg/mg protein endotoxin (<1 EU/μg)
UniProt accession no.   P10600
shipped in   dry ice

Description

General description

Product Source: E. coli.

TGF-β-III (transforming growth factor beta III) is one of three closely related mammalian members of the large TGF-β superfamily. TGF-β-I, TGF-β-II and TGF-β-III are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial mesenchymal transition. TGF-β3 regulates molecules involved in cellular adhesion and extracellular matrix formation during the process of palate development. TGF-β3 also plays an essential role in controlling the development of lungs in mammals and controls wound healing by regulating the movements of epidermal and dermal cells in injured skin. Recombinant TGF-β-III is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

Application

Research Category
Stem Cell Research

Research Sub Category
Growth Factors & Receptors

Quality

Determined by TGF-β-III’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.

Physical form

Product is filtered through a 0.2 micron filter before lyophilization.

Storage and Stability

Store at -20°C for up to 6 months from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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